Searchable abstracts of presentations at key conferences in endocrinology

ea0029p554 | Diabetes | ICEECE2012

High-fructose diet, an animal model of insulin resistance, causes mitochondrial dysfunction by altering the activity of respiratory chain complex I

Sanchez-Martin C , Sanz M , Detaille D , Recio-Cordova J , Peralta F , R-Villanueva G

Introduction: The current epidemic of Type 2 Diabetes Mellitus (T2DM) and obesity is positively correlated with a rise in consumption of high-fructose syrups and refined carbohydrates. Recent reports have showed that feeding rodent a high-fructose diet leads to insulin resistance, glucose intolerance and dyslipidaemia. Nevertheless, its mitochondrial effects has not been fully studied yet.Aim: We decided to explore the alterations in mitochondrial bioene...